The Bide-a-Wee Mouse Home has sent the orphan mouse, Nibbles, to spend Thanksgiving with Jerry. But Jerry’s cupboard is bare, and Nibbles is always hungry. They start by raiding Tom’s milk dish, but Tom wakes up and drains it. Fortunately, Mammy has just put out a huge Thanksgiving feast, just ready for the raiding. And that’s just what Jerry and Nibbles do, grabbing Pilgrim hats from the table decorations. All goes fairly well until Nibbles eats a whole orange, which is way too big for him. Jerry smacks him with a spoon, which sends the orange flying, right into Tom’s mouth. Tom stalks up to the table in a feather duster, which turns into an Indian headdress. Battle follows, featuring Tom sending flaming cat-tails after the mice, and culminating in a champagne bottle launching Tom into the dish cabinet, which crashes down. Tom waves a white flag, and all three sit down to a polite dinner, but Nibbles eats the whole turkey before anyone else can touch it.
