The gang is headed to Great Skull Island to meet Daphne’s friend, Lisa, for her 18th birthday. Unfortunately, a vampire has turned up to crash the party, and he comes after Daphne after Lisa trades rooms with Daphne & Velma. Lisa’s guardian, her Uncle Leon, reveals that an old family curse may have caught up to them, and the vampire who is stalking Lisa is supposedly her grandfather! The gang must trap the vampire before he turns all of them into vampires!